Medically Reviewed by: Dr. (Prof.) Kshitij Saxena, M.D. (Dermatology)
Last Updated: January 22, 2026
When hair loss progresses from “mild shedding” to advanced hair thinning, traditional shampoos and oils are no longer enough. Patients often find themselves choosing between three clinical powerhouses: Mesotherapy, Platelet-Rich Plasma (PRP), and Growth Factor Concentrate (GFC).
At our Lucknow clinic, we utilize these regenerative therapies to target Androgenetic Alopecia and Telogen Effluvium at the root level. This guide breaks down which treatment is superior for your specific stage of hair loss.
Key Takeaways: Hair Restoration Comparison
- Best for Nutrition: Mesotherapy provides vitamins and DHT blockers but is often used for early thinning or as a maintenance booster.
- The Clinical Standard: PRP uses your own blood’s platelets to stimulate dormant follicles; best for mild-to-moderate thinning.
- Advanced Potency: GFC is a highly concentrated, pure growth factor treatment that typically delivers faster results in fewer sessions than PRP.
- Efficiency: While PRP requires 4–6 sessions, GFC often shows comparable or better density in just 3–4 sessions.
Safety & Quality Standards: At our Lucknow clinic, we prioritize patient safety by using only CDSCO (Central Drugs Standard Control Organisation) approved vials for all GFC and PRP procedures. This ensures the highest level of sterility and growth factor concentration.
1. Mesotherapy: The “Nutrient Cocktail”
Mesotherapy is a non-surgical procedure where a customized blend of vitamins, minerals, amino acids, and DHT blockers is injected into the mesoderm (middle layer) of the scalp.
- How it works: It bypasses the digestive system to deliver “hair food” directly to weak roots.
- Best for: Patients with hair loss due to nutritional deficiencies, stress, or long-term pollution exposure.
- Results: Usually requires 6–8 sessions for visible improvement in hair luster and volume.
2. PRP (Platelet-Rich Plasma): The Established Regenerative Therapy
PRP is an autologous treatment, meaning it uses your own blood. The blood is centrifuged to separate the plasma rich in platelets, which is then re-injected into thinning areas.
- How it works: Platelets release growth factors that prolong the anagen (growth) phase of the hair cycle and improve blood supply to the follicles.
- Clinical Efficacy: Studies show PRP can increase hair density by approximately 35% over a standard course.
- Ideal Candidate: Individuals in the early stages of androgenetic alopecia with active, though thinning, follicles.
3. GFC (Growth Factor Concentrate): The Advanced Evolution
GFC is considered a refined, “next-generation” version of PRP. While PRP injects platelets that later release growth factors, GFC extracts and concentrates those growth factors in a lab setting before injection.
- The GFC Advantage: It is a standardized, acellular (no red or white blood cells) treatment, which significantly reduces the risk of post-procedural inflammation and pain.
- Potency: GFC can deliver up to 10 times more growth factor concentration than standard PRP.
- Efficacy in Advanced Thinning: Clinical trials have demonstrated a 50% increase in hair density with GFC compared to 35% with PRP.
- Why Choose GFC: It offers faster visible improvements (often by the 2nd or 3rd session) and requires fewer clinic visits.
Comparison at a Glance
| Feature | Mesotherapy | PRP Therapy | GFC Treatment |
| Primary Ingredient | Vitamins, Minerals, DHT Blockers | Concentrated Platelets | Pure Growth Factors |
| Source | Laboratory-formulated | Patient’s own blood | Patient’s own blood |
| Best For | Early thinning & Scalp health | Mild-to-moderate thinning | Moderate-to-advanced thinning |
| Typical Sessions | 6–10 | 4–6 | 3–4 |
| Pain Level | Very Low | Mild (Tingling/Swelling) | Minimal (Very comfortable) |
Which is Better for Advanced Thinning?
For patients in Lucknow dealing with noticeable scalp visibility or widening parts, GFC Treatment is often the superior clinical choice. Its ability to deliver a higher concentration of Vascular Endothelial Growth Factor (VEGF) and Insulin-like Growth Factor (IGF-1) ensures more robust stimulation of dormant follicles than Mesotherapy or standard PRP.
However, the most effective approach is often a Sequential Protocol. Dr. (Prof.) Kshitij Saxena frequently recommends starting with GFC for rapid density improvement, followed by Mesotherapy sessions to maintain the nutrient balance of the scalp.
Frequently Asked Questions (FAQ)
1. Is the treatment painful?
Mesotherapy and GFC are generally very well-tolerated. PRP may cause slight soreness for 24 hours as the platelets activate within the scalp.
2. When will I see results?
Reduced hair fall is often noticed after the first session of GFC. Visible density improvements typically appear between 3 to 6 months across all three modalities.
3. Are these treatments permanent?
Hair restoration is a journey, not a one-time event. While these treatments significantly delay balding, maintenance sessions every 6–12 months are recommended to sustain results.
Ready to Restore Your Hair Confidence?
Contact Dr. Kshitij Saxena’s Skin & Hair Clinic Today:
- 📍 Location: K-38, Quila Rd, near Power House Chauraha, Ashiyana, Lucknow
- 📞 Phone/WhatsApp: 092080 15391
- 📧 Email: drkjsv@gmail.com
Schedule your specialized hair consultation today to discover which regenerative therapy GFC, PRP, or Mesotherapy is right for your scalp. During your visit, Dr. (Prof.) Saxena will perform a clinical assessment to create a personalized treatment plan designed to stop hair fall and trigger new growth.
Say goodbye to thinning patches and expensive, ineffective topical solutions. Your journey to a fuller head of hair starts with a medical-grade plan.
About the author
Dr. (Prof.) Kshitij Saxena is a renowned Dermatologist and Cosmetologist based in Ashiyana, Lucknow. With an M.D. in Dermatology and over 15 years of clinical and academic experience, he combines rigorous medical precision with aesthetic artistry. As a respected Professor in the field, he ensures that every treatment at his clinic is backed by the latest evidence and delivered using FDA-approved technology for safe, medical-grade results.
Disclaimer:This blog post is for informational purposes only and should not replace professional medical advice. Results from hair restoration treatments like GFC, PRP, and Mesotherapy vary by individual based on the stage of hair loss and underlying health factors. Consult with Dr. (Prof.) Kshitij Saxena to determine the most appropriate treatment for your specific situation.